Preparation of Solid Dispersion to Enhance the Dissolution Behaviour and Increase Efficacy and Activity of the Drug Substance
Alpesh Bhadarka G and Rohit Dave H*
ABSTRACT
Solid dispersion is a well-established technique to improve the solubility and bioavailability of poorly water-soluble drugs. This study explores the formulation and characterization of SD systems using various carriers to enhance drug dissolution rates and stability. The prepared solid dispersions demonstrate reduced crystallinity of the drug, indicating transformation into an amorphous state, which contributes to improve solubility. Physicochemical evaluations confirm the successful dispersion of the drug within the carrier matrix without significant interactions. Dissolution studies reveal a significant enhancement in the drug release profile compared to the pure crystalline drug. This research underlines the potential of solid dispersion technology as an effective and practical approach to overcome solubility limitation in pharmaceutical development
