Formulation and Evaluation of Colon Targeted Matrix Tablets Containing Extract of Haplophyllum Tuberculatum (Hazaa) for Colorectal Cancer Management
Fatehalrahman Faris Magbool1*, Asim Halfawi Shargi2 and Mohammed E Adam3
Abstract
Objective: The objective of the present study is to formulate colon targeted matrix tablets containing Haplophyllum tuberculatum extract using guar gum alone or in combination with either HPMC K15M, with Eudragit S100, or with both them. Methods: The Hazaa colon targeted matrix tablets were prepared by wet granulation method. The prepared matrix tablets were evaluated for the weight variation, hardness, friability, and in-vitro drug release study in three different media.
Results: Despite good understanding of the molecular basis of the disease and advances in treatment, globally cancer is still a major cause of death. Estimates are that it will surpass cardiovascular disease as the leading cause of death, with higher incidences in the developing countries that have minimal resources. The formulations showed compliance with Pharmacopeial standards except that containing guar gum alone. There was no interaction between drug, polymer and other excipients. It was confirmed by FTIR studies. Among the formulations, GHE2 (i.e. containing triple polymer mixture) showed good results in release retardation and other physicochemical properties of matrix tablets when compare to other formulations. The optimum formulation (GHE2) was stable when it was stored at 450/75% RH for 3 months.
Conclusion: The formulation (GHE2) is considered the most suitable formula for targeting the colon. The current results for the first time suggest that Hazaa plant water dry extracts are promising anticancer reagents. Subsequently, the results can be used to develop a prevention agent for the treatment of human cancers.
